New Complexes based on Sulfathiazole; Synthesis, Characterization and Toxicity Assessment against Chlorella Vulgaris Microchlorophyte

The reactions between sulfathiazole (Hst) and Ni(II), Zn(II), Pd(II), and Ag(I) in presence and absence of N,N-donors (2,2‟-bipyridyl or 2-aminopyrimidine) were reported. Their structures were noted by using spectral {IR, NMR (1H, 13C), UV–Vis, and EI- and muldy-mass} and physical (elemental analyses, molar conductivities and TGA behaviour) measurements. Hst coordinates to the metal ions through (i) the deprotonated N-thiazole atom in mono-negative monodentate manner or (ii) the deprotonated N-thiazole and SO2-O atoms as mono negative bidentate ligand. The stoichiometries and the formation constants of Hst complexes in solution were calculated spectrophotometrically using molar ratio and Job‟s methods. Moreover, the toxicity of Hst and its complexes against the microchlorophyte (Chlorella vulgaris) have been measured and assessed in comparison to the free metal ions .

Keywords: Complexes, Sulfathiazole, Spectra, Stoichiometry, Chlorella vulgaris.